Dr. Nicole Paulk, Ph.D.

Assistant Adjunct Professor, UCSF

Dr. Nicole Paulk is an Assistant Adjunct Professor and K01 Fellow in Viral Gene Therapy at UCSF in San Francisco. Dr. Paulk has a BS in Medical Microbiology, a PhD in Viral Gene Therapy and Regenerative Hepatology from OHSU with Dr. Markus Grompe, and completed her Postdoctoral Fellowship in Human Gene Therapy with Dr. Mark Kay at Stanford University. She is a pioneer in the development of next-generation AAV gene delivery platforms and has engineered payloads for gene repair and gene transfer for numerous rare diseases, utilized directed evolution to evolve capsid serotypes with novel tropisms, and has applied comparative proteomic approaches to interrogate challenges in vector manufacturing. Dr. Paulk’s translational research lab at UCSF now develops solutions for the biggest problems in gene therapy: cost, delivery and efficacy, with a focus on treatments for rare diseases and cancer.